Ptaquiloside-induced early-stage urothelial lesions show increased cell proliferation and intact β-catenin and E-cadherin expression Running title: Immunohistochemistry of ptaquiloside-induced lesions
نویسندگان
چکیده
aAbel Salazar Institute for Biomedical Sciences (ICBAS), University of Porto, Largo Prof. Abel Salazar 2, 4099-003 Porto, Portugal. bLEPAE, Chemical Engineering Department, Engineering Faculty, University of Porto, Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal. cVeterinary Sciences Department, CECAV, University of Trás-os-Montes and Alto Douro, Quinta de Prados 5001-801 Vila Real, Portugal.
منابع مشابه
Ptaquiloside-induced early-stage urothelial lesions show increased cell proliferation and intact β-catenin and E-cadherin expression.
Bracken (Pteridium aquilinum) is a carcinogenic plant whose main toxin, ptaquiloside, causes cancer in farm and laboratory animals. Ptaquiloside contaminates underground waters as well as meat and milk from bracken-grazing animals and is a suspected human carcinogen. A better understanding of the underlying mechanisms of carcinogenesis can be achieved by studying the early stages of this proces...
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The multifactorial origin of gastric cancer encompasses environmental factors mainly associated with diet. Pteridium aquilinum-bracken fern-is the only higher plant known to cause cancer in animals. Its carcinogenic toxin, ptaquiloside, has been identified in milk of cows and groundwater. Humans can be directly exposed by consumption of the plant, contaminated water or milk, and spore inhalatio...
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